Additional Studies in the Patient with a GIST Succinate dehydrogenase-deficient GISTs

If the clinical history is suspicious for a syndromic GIST and/or the morphology is suspicious (epithelioid GISTs for example), your pathologist can order an SDHB immunohistochemical stain to rule out the following syndromes:

• Carney Triad:  GISTs, paraganglioma and pulmonary chondroma

• Carney-Stratakis:  GISTs and paragangliomas

If SDHB is lost (negative) on immunohistochemical evaluation, that finding is compatible with a syndromic GIST and the patient will be able to get an appropriate follow-up.

Additional Tests Available for High-Risk GISTs